Important: Valproate and Topiramate updates

Valproate update

Men taking valproate and their partners are being advised by the Medicines and Healthcare products Regulatory Agency (MHRA) to use effective contraception because of new data suggesting a potential small increased risk of harm to children if valproate is used by a father at conception.

MHRA have published a Drug Safety Update, which includes information and advice for healthcare professionals and patients.

Read the MHRA news item on valproate use in men

What pharmacy teams need to do

• remind patients on valproate that they must not stop taking their treatment without advice from their specialist
• continue to dispense / prescribe valproate in line with guidelines
• be prepared to discuss the new advice with their patients
• make sure patients receive the patient card and patient guide
• display the poster for pharmacy teams